Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo.

Citation: Abram M, Jakubiec M, Reeb K, Cheng MH, Gedschold R, Rapacz A, Mogilski S, Socała K, Nieoczym D, Szafarz M, Latacz G, Szulczyk B, Kalinowska-Tłuścik J, Gawel K, Esguerra CV, Wyska E, Müller CE, Bahar I, Fontana ACK, Wlaź P, Kamiński RM, Kamiński K.: Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo. J Med Chem, Volume 65 (17), 2022
Authors: Abram M, Bahar I, Cheng MH, Esguerra CV, Fontana ACK, Gawel K, Gedschold R, Jakubiec M, Kalinowska-Tłuścik J, Kamiński K., Kamiński RM, Latacz G, Mogilski S, Müller CE, Nieoczym D, Rapacz A, Reeb K, Socała K, Szafarz M, Szulczyk B, Wlaź P, Wyska E
Journal: J Med Chem
Year: 2022
DOI: 10.1021/acs.jmedchem.2c00534
PubMed: 35984707
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Discovery of (<i>R</i>)-<i>N</i>-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [<b>(<i>R</i>)-AS-1</b>], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity <i>In Vivo</i>.