Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.

Citation: Certal V, Halley F, Virone-Oddos A, Delorme C, Karlsson A, Rak A, Thompson F, Filoche-Rommé B, El-Ahmad Y, Carry JC, Abecassis PY, Lejeune P, Vincent L, Bonnevaux H, Nicolas JP, Bertrand T, Marquette JP, Michot N, Benard T, Below P, Vade I, Chatreaux F, Lebourg G, Pilorge F, Angouillant-Boniface O, Louboutin A, Lengauer C, Schio L.: Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers. J Med Chem, Volume 55 (10), 2012
Authors: Abecassis PY, Angouillant-Boniface O, Below P, Benard T, Bertrand T, Bonnevaux H, Carry JC, Certal V, Chatreaux F, Delorme C, El-Ahmad Y, Filoche-Rommé B, Halley F, Karlsson A, Lebourg G, Lejeune P, Lengauer C, Louboutin A, Marquette JP, Michot N, Nicolas JP, Pilorge F, Rak A, Schio L., Thompson F, Vade I, Vincent L, Virone-Oddos A
Journal: J Med Chem
Year: 2012
DOI: 10.1021/jm300241b
PubMed: 22524426
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