Citation

Goldstein DM, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, Chen J, Bingenheimer W, Dalrymple SA, Dunn J, Farrell R, Frauchiger S, La Fargue J, Ghate M, Graves B, Hill RJ, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Stahl M, Sung ML, Suttman RT, Sjogren EB, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H.: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem, Volume 54 (7), 2011

Authors

Arzeno H, Bingenheimer W, Chen J, Dalrymple SA, Dewdney N, Dunn J, Farrell R, Frauchiger S, Gabriel T, Ghate M, Goldstein DM, Graves B, Hill RJ, Kuglstatter A, La Fargue J, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Sjogren EB, Soth M, Stahl M, Sung ML, Suttman RT, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H.

Journal

J Med Chem

Year

2011

DOI

10.1021/jm101423y

PubMed

21375264

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