{"data":{"id":3332,"citation":"Goldstein DM, Soth M, Gabriel T, Dewdney N, Kuglstatter A, Arzeno H, Chen J, Bingenheimer W, Dalrymple SA, Dunn J, Farrell R, Frauchiger S, La Fargue J, Ghate M, Graves B, Hill RJ, Li F, Litman R, Loe B, McIntosh J, McWeeney D, Papp E, Park J, Reese HF, Roberts RT, Rotstein D, San Pablo B, Sarma K, Stahl M, Sung ML, Suttman RT, Sjogren EB, Tan Y, Trejo A, Welch M, Weller P, Wong BR, Zecic H.: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38\u03b1 mitogen-activated protein kinase. J Med Chem, Volume 54 (7), 2011","title":"Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38\u03b1 mitogen-activated protein kinase.","doi":"10.1021\/jm101423y","doi_url":"https:\/\/doi.org\/10.1021\/jm101423y","pmid":"21375264","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/21375264\/","year":2011,"journal":"J Med Chem","volume":"54","issue":"7","page":"2255-2265","authors":[{"first_name":"Arzeno H","last_name":null,"full_name":null},{"first_name":"Bingenheimer W","last_name":null,"full_name":null},{"first_name":"Chen J","last_name":null,"full_name":null},{"first_name":"Dalrymple SA","last_name":null,"full_name":null},{"first_name":"Dewdney N","last_name":null,"full_name":null},{"first_name":"Dunn J","last_name":null,"full_name":null},{"first_name":"Farrell R","last_name":null,"full_name":null},{"first_name":"Frauchiger S","last_name":null,"full_name":null},{"first_name":"Gabriel T","last_name":null,"full_name":null},{"first_name":"Ghate M","last_name":null,"full_name":null},{"first_name":"Goldstein DM","last_name":null,"full_name":null},{"first_name":"Graves B","last_name":null,"full_name":null},{"first_name":"Hill RJ","last_name":null,"full_name":null},{"first_name":"Kuglstatter A","last_name":null,"full_name":null},{"first_name":"La Fargue J","last_name":null,"full_name":null},{"first_name":"Li F","last_name":null,"full_name":null},{"first_name":"Litman R","last_name":null,"full_name":null},{"first_name":"Loe B","last_name":null,"full_name":null},{"first_name":"McIntosh J","last_name":null,"full_name":null},{"first_name":"McWeeney D","last_name":null,"full_name":null},{"first_name":"Papp E","last_name":null,"full_name":null},{"first_name":"Park J","last_name":null,"full_name":null},{"first_name":"Reese HF","last_name":null,"full_name":null},{"first_name":"Roberts RT","last_name":null,"full_name":null},{"first_name":"Rotstein D","last_name":null,"full_name":null},{"first_name":"San Pablo B","last_name":null,"full_name":null},{"first_name":"Sarma K","last_name":null,"full_name":null},{"first_name":"Sjogren EB","last_name":null,"full_name":null},{"first_name":"Soth M","last_name":null,"full_name":null},{"first_name":"Stahl M","last_name":null,"full_name":null},{"first_name":"Sung ML","last_name":null,"full_name":null},{"first_name":"Suttman RT","last_name":null,"full_name":null},{"first_name":"Tan Y","last_name":null,"full_name":null},{"first_name":"Trejo A","last_name":null,"full_name":null},{"first_name":"Welch M","last_name":null,"full_name":null},{"first_name":"Weller P","last_name":null,"full_name":null},{"first_name":"Wong BR","last_name":null,"full_name":null},{"first_name":"Zecic H.","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3332","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3332","created_at":"2024-05-21T20:11:44.000000Z","updated_at":null}}