Citation

Fuchino K, Mitsuoka Y, Masui M, Kurose N, Yoshida S, Komano K, Yamamoto T, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Miyajima H, Hiroyama S, Koyabu K, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI.: Rational Design of Novel 1,3-Oxazine Based β-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust Aβ Reduction in the Brain. J Med Chem, Volume 61 (12), 2018

Authors

Ando S, Borghys H, Dhuyvetter D, Fuchino K, Fukushima T, Gijsen HJM, Hiroyama S, Hosono M, Iso Y, Ito H, Kido Y, Komano K, Koyabu K, Kurose N, Kusakabe KI., Masui M, Mitsuoka Y, Miyajima H, Ogawa M, Ohnishi S, Sakaguchi G, Unemura C, Yamamoto T, Yamano Y, Yoshida S

Journal

J Med Chem

Year

2018

DOI

10.1021/acs.jmedchem.8b00002

PubMed

29733614

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