{"data":{"id":3239,"citation":"Fuchino K, Mitsuoka Y, Masui M, Kurose N, Yoshida S, Komano K, Yamamoto T, Ogawa M, Unemura C, Hosono M, Ito H, Sakaguchi G, Ando S, Ohnishi S, Kido Y, Fukushima T, Miyajima H, Hiroyama S, Koyabu K, Dhuyvetter D, Borghys H, Gijsen HJM, Yamano Y, Iso Y, Kusakabe KI.: Rational Design of Novel 1,3-Oxazine Based \u03b2-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust A\u03b2 Reduction in the Brain. J Med Chem, Volume 61 (12), 2018","title":"Rational Design of Novel 1,3-Oxazine Based \u03b2-Secretase (BACE1) Inhibitors: Incorporation of a Double Bond To Reduce P-gp Efflux Leading to Robust A\u03b2 Reduction in the Brain.","doi":"10.1021\/acs.jmedchem.8b00002","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.8b00002","pmid":"29733614","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/29733614\/","year":2018,"journal":"J Med Chem","volume":"61","issue":"12","page":"5122-5137","authors":[{"first_name":"Ando S","last_name":null,"full_name":null},{"first_name":"Borghys H","last_name":null,"full_name":null},{"first_name":"Dhuyvetter D","last_name":null,"full_name":null},{"first_name":"Fuchino K","last_name":null,"full_name":null},{"first_name":"Fukushima T","last_name":null,"full_name":null},{"first_name":"Gijsen HJM","last_name":null,"full_name":null},{"first_name":"Hiroyama S","last_name":null,"full_name":null},{"first_name":"Hosono M","last_name":null,"full_name":null},{"first_name":"Iso Y","last_name":null,"full_name":null},{"first_name":"Ito H","last_name":null,"full_name":null},{"first_name":"Kido Y","last_name":null,"full_name":null},{"first_name":"Komano K","last_name":null,"full_name":null},{"first_name":"Koyabu K","last_name":null,"full_name":null},{"first_name":"Kurose N","last_name":null,"full_name":null},{"first_name":"Kusakabe KI.","last_name":null,"full_name":null},{"first_name":"Masui M","last_name":null,"full_name":null},{"first_name":"Mitsuoka Y","last_name":null,"full_name":null},{"first_name":"Miyajima H","last_name":null,"full_name":null},{"first_name":"Ogawa M","last_name":null,"full_name":null},{"first_name":"Ohnishi S","last_name":null,"full_name":null},{"first_name":"Sakaguchi G","last_name":null,"full_name":null},{"first_name":"Unemura C","last_name":null,"full_name":null},{"first_name":"Yamamoto T","last_name":null,"full_name":null},{"first_name":"Yamano Y","last_name":null,"full_name":null},{"first_name":"Yoshida S","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3239","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3239","created_at":"2024-05-21T09:16:30.000000Z","updated_at":null}}