Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides.

Citation: Rueeger H, Lueoend R, Rogel O, Rondeau JM, Möbitz H, Machauer R, Jacobson L, Staufenbiel M, Desrayaud S, Neumann U.: Discovery of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid β-peptides. J Med Chem, Volume 55 (7), 2012
Authors: Desrayaud S, Jacobson L, Lueoend R, Machauer R, Möbitz H, Neumann U., Rogel O, Rondeau JM, Rueeger H, Staufenbiel M
Journal: J Med Chem
Year: 2012
DOI: 10.1021/jm300069y
PubMed: 22380629
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