{"data":{"id":3158,"citation":"Rueeger H, Lueoend R, Rogel O, Rondeau JM, M\u00f6bitz H, Machauer R, Jacobson L, Staufenbiel M, Desrayaud S, Neumann U.: Discovery of cyclic sulfone hydroxyethylamines as potent and selective \u03b2-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid \u03b2-peptides. J Med Chem, Volume 55 (7), 2012","title":"Discovery of cyclic sulfone hydroxyethylamines as potent and selective \u03b2-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure-based design and in vivo reduction of amyloid \u03b2-peptides.","doi":"10.1021\/jm300069y","doi_url":"https:\/\/doi.org\/10.1021\/jm300069y","pmid":"22380629","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/22380629\/","year":2012,"journal":"J Med Chem","volume":"55","issue":"7","page":"3364-3386","authors":[{"first_name":"Desrayaud S","last_name":null,"full_name":null},{"first_name":"Jacobson L","last_name":null,"full_name":null},{"first_name":"Lueoend R","last_name":null,"full_name":null},{"first_name":"Machauer R","last_name":null,"full_name":null},{"first_name":"M\u00f6bitz H","last_name":null,"full_name":null},{"first_name":"Neumann U.","last_name":null,"full_name":null},{"first_name":"Rogel O","last_name":null,"full_name":null},{"first_name":"Rondeau JM","last_name":null,"full_name":null},{"first_name":"Rueeger H","last_name":null,"full_name":null},{"first_name":"Staufenbiel M","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3158","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3158","created_at":"2024-05-21T09:16:07.000000Z","updated_at":null}}