Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

Citation: Storer RI, Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, de Oliveira CA, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Westbrook D, Wheeler S, Whitlock GA, Wright J.: Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors. J Med Chem, Volume 57 (12), 2014
Authors: Brennan PE, Brown AD, Bungay PJ, Conlon KM, Corbett MS, de Oliveira CA, DePianta RP, Fish PV, Heifetz A, Ho DK, Jessiman AS, McMurray G, Roberts LR, Root JA, Shanmugasundaram V, Shapiro MJ, Skerten M, Storer RI, Westbrook D, Wheeler S, Whitlock GA, Wright J.
Journal: J Med Chem
Year: 2014
DOI: 10.1021/jm5003292
PubMed: 24878222
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