Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

Citation: Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS.: Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. J Med Chem, Volume 56 (20), 2013
Authors: Chen XT, Cowan CL, Crombie AL, Dewire SM, Gotchev D, Koblish M, Liu G, Pitis P, Rominger DH, Violin JD, Yamashita DS., Yuan C
Journal: J Med Chem
Year: 2013
DOI: 10.1021/jm4010829
PubMed: 24063433
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