{"data":{"id":1193,"citation":"Chen XT, Pitis P, Liu G, Yuan C, Gotchev D, Cowan CL, Rominger DH, Koblish M, Dewire SM, Crombie AL, Violin JD, Yamashita DS.: Structure-activity relationships and discovery of a G protein biased \u03bc opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. J Med Chem, Volume 56 (20), 2013","title":"Structure-activity relationships and discovery of a G protein biased \u03bc opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.","doi":"10.1021\/jm4010829","doi_url":"https:\/\/doi.org\/10.1021\/jm4010829","pmid":"24063433","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/24063433\/","year":2013,"journal":"J Med Chem","volume":"56","issue":"20","page":"8019-8031","authors":[{"first_name":"Chen XT","last_name":null,"full_name":null},{"first_name":"Cowan CL","last_name":null,"full_name":null},{"first_name":"Crombie AL","last_name":null,"full_name":null},{"first_name":"Dewire SM","last_name":null,"full_name":null},{"first_name":"Gotchev D","last_name":null,"full_name":null},{"first_name":"Koblish M","last_name":null,"full_name":null},{"first_name":"Liu G","last_name":null,"full_name":null},{"first_name":"Pitis P","last_name":null,"full_name":null},{"first_name":"Rominger DH","last_name":null,"full_name":null},{"first_name":"Violin JD","last_name":null,"full_name":null},{"first_name":"Yamashita DS.","last_name":null,"full_name":null},{"first_name":"Yuan C","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/1193","landing_page":"https:\/\/molmedb.upol.cz\/publication\/1193","created_at":"2021-01-20T08:40:44.000000Z","updated_at":null}}