Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.

Publication

Citation
Scanio MJ, Shi L, Drizin I, Gregg RJ, Atkinson RN, Thomas JB, Johnson MS, Chapman ML, Liu D, Krambis MJ, Liu Y, Shieh CC, Zhang X, Simler GH, Joshi S, Honore P, Marsh KC, Knox A, Werness S, Antonio B, Krafte DS, Jarvis MF, Faltynek CR, Marron BE, Kort ME.: Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain. Bioorg Med Chem, Volume 18 (22), 2010
Authors
Antonio B, Atkinson RN, Chapman ML, Drizin I, Faltynek CR, Gregg RJ, Honore P, Jarvis MF, Johnson MS, Joshi S, Knox A, Kort ME., Krafte DS, Krambis MJ, Liu D, Liu Y, Marron BE, Marsh KC, Scanio MJ, Shi L, Shieh CC, Simler GH, Thomas JB, Werness S, Zhang X
Journal
Bioorg Med Chem
Year
2010
PubMed
20965738
Machine-readable
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Palacky University Olomouc

Palacky University Olomouc

Faculty of Science

Department of Physical Chemistry

tř. 17. listopadu 1192/12

771 46 Olomouc

Czech Republic

How to cite?

Juračka J., Šrejber M., Melíková M., Bazgier V., Berka K.: MolMeDB: Molecules on Membranes Database. Database, Volume 2019, 2019, baz078, https://doi.org/10.1093/database/baz078

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