Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

Publication

Citation
Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A.: Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett, Volume 27 (11), 2017
Authors
Dong S, Ehrhart J, Ferguson R, Frie J, Fu Q, Gu X, Guo ZZ, Haimbach RE, Hampton C, Hu M, Liu J, Margulis M, Morissette P, Owens K, Pai LY, Pasternak A., Priest BT, Roy S, Shi ZC, Sullivan K, Tang H, Thomas-Fowlkes B, Tong V, VanGelder K, Weinglass A, Wu Z, Xu S, Yu Y, Zingaro GJ
Journal
Bioorg Med Chem Lett
Year
2017
PubMed
28431879
Machine-readable
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Palacky University Olomouc

Palacky University Olomouc

Faculty of Science

Department of Physical Chemistry

tř. 17. listopadu 1192/12

771 46 Olomouc

Czech Republic

How to cite?

Juračka J., Šrejber M., Melíková M., Bazgier V., Berka K.: MolMeDB: Molecules on Membranes Database. Database, Volume 2019, 2019, baz078, https://doi.org/10.1093/database/baz078

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