Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Publication

Citation
Cameron K., Kung D., Kalgutkar A., Kurumbail R., Miller R., Salatto C., Ward J., Withka J., Bhattacharya S., Boehm M., Borzilleri K., Brown J., Calabrese M., Caspers N., Cokorinos E., Conn E., Dowling M., Edmonds D., Eng H., Fernando D., Frisbie R., Hepworth D., Landro J., Mao Y., Rajamohan F., Reyes A., Rose C., Ryder T., Shavnya A., Smith A., Tu M., Wolford A., Xiao J.: Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. Journal of Medicinal Chemistry, Volume 59 (17), 2016
Authors
Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar, Ravi G. Kurumbail, Russell Miller, Christopher T. Salatto, Jessica Ward, Jane M. Withka, Samit K. Bhattacharya, Markus Boehm, Kris A. Borzilleri, Janice A. Brown, Matthew Calabrese, Nicole L. Caspers, Emily Cokorinos, Edward L. Conn, Matthew S. Dowling, David J. Edmonds, Heather Eng, Dilinie P. Fernando, Richard Frisbie, David Hepworth, James Landro, Yuxia Mao, Francis Rajamohan, Allan R. Reyes, Colin R. Rose, Tim Ryder, Andre Shavnya, Aaron C. Smith, Meihua Tu, Angela C. Wolford, Jun Xiao
Journal
Journal of Medicinal Chemistry
Year
2016
Machine-readable
REST APIRDF
Palacky University Olomouc

Palacky University Olomouc

Faculty of Science

Department of Physical Chemistry

tř. 17. listopadu 1192/12

771 46 Olomouc

Czech Republic

How to cite?

Juračka J., Šrejber M., Melíková M., Bazgier V., Berka K.: MolMeDB: Molecules on Membranes Database. Database, Volume 2019, 2019, baz078, https://doi.org/10.1093/database/baz078

Follow us

FacebookGithub

Financial Support

  • MolMeDB interoperability with UniProt and SwissLipids – MEYS Czech-Swiss project ELIXIR-IMPACT 8K0208 (2026–2028)
ELIXIRGAČRUP Olomouc