Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Citation: Fensome A., Ambler C., Arnold E., Banker M., Brown M., Chrencik J., Clark J., Dowty M., Efremov I., Flick A., Gerstenberger B., Gopalsamy A., Hayward M., Hegen M., Hollingshead B., Jussif J., Knafels J., Limburg D., Lin D., Lin T., Pierce B., Saiah E., Sharma R., Symanowicz P., Telliez J., Trujillo J., Vajdos F., Vincent F., Wan Z., Xing L., Yang X., Yang X., Zhang L.: Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S )-2,2-Difluorocyclopropyl)((1 R ,5 S )-3-(2-((1-methyl-1 H -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). Journal of Medicinal Chemistry, Volume 61 (19), 2018
Authors: Andrew Fensome, Catherine M. Ambler, Eric Arnold, Mary Ellen Banker, Matthew F. Brown, Jill Chrencik, James D. Clark, Martin E. Dowty, Ivan V. Efremov, Andrew Flick, Brian S. Gerstenberger, Ariamala Gopalsamy, Matthew M. Hayward, Martin Hegen, Brett D. Hollingshead, Jason Jussif, John D. Knafels, David C. Limburg, David Lin, Tsung H. Lin, Betsy S. Pierce, Eddine Saiah, Raman Sharma, Peter T. Symanowicz, Jean-Baptiste Telliez, John I. Trujillo, Felix F. Vajdos, Fabien Vincent, Zhao-Kui Wan, Li Xing, Xiaojing Yang, Xin Yang, Liying Zhang
Journal: Journal of Medicinal Chemistry
Year: 2018
DOI: 10.1021/acs.jmedchem.8b00917
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Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)