Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

Citation: Swanson DM, Savall BM, Coe KJ, Schoetens F, Koudriakova T, Skaptason J, Wall J, Rech J, Deng X, De Angelis M, Everson A, Lord B, Wang Q, Ao H, Scott B, Sepassi K, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA.: Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem, Volume 59 (18), 2016
Authors: Ao H, Bhattacharya A, Carruthers NI, Coe KJ, De Angelis M, Deng X, Everson A, Koudriakova T, Letavic MA., Lord B, Lovenberg TW, Rech J, Savall BM, Schoetens F, Scott B, Sepassi K, Skaptason J, Swanson DM, Wall J, Wang Q
Journal: J Med Chem
Year: 2016
DOI: 10.1021/acs.jmedchem.6b00989
PubMed: 27548392
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