Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.

Citation: Hudkins RL, Josef KA, Becknell NC, Aimone LD, Lyons JA, Mathiasen JR, Gruner JA, Raddatz R.: Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity. Bioorg Med Chem Lett, Volume 24 (5), 2014
Authors: Aimone LD, Becknell NC, Gruner JA, Hudkins RL, Josef KA, Lyons JA, Mathiasen JR, Raddatz R.
Journal: Bioorg Med Chem Lett
Year: 2014
DOI: 10.1016/j.bmcl.2014.01.061
PubMed: 24513042
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