Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.

Citation: Chaturvedula PV, Mercer SE, Pin SS, Thalody G, Xu C, Conway CM, Keavy D, Signor L, Cantor GH, Mathias N, Moench P, Denton R, Macci R, Schartman R, Whiterock V, Davis C, Macor JE, Dubowchik GM.: Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery. Bioorg Med Chem Lett, Volume 23 (11), 2013
Authors: Cantor GH, Chaturvedula PV, Conway CM, Davis C, Denton R, Dubowchik GM., Keavy D, Macci R, Macor JE, Mathias N, Mercer SE, Moench P, Pin SS, Schartman R, Signor L, Thalody G, Whiterock V, Xu C
Journal: Bioorg Med Chem Lett
Year: 2013
DOI: 10.1016/j.bmcl.2013.04.012
PubMed: 23632269
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