Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.

Publication

Citation
Clark CG, Rossi KA, Corte JR, Fang T, Smallheer JM, De Lucca I, Nirschl DS, Orwat MJ, Pinto DJP, Hu Z, Wang Y, Yang W, Jeon Y, Ewing WR, Myers JE, Sheriff S, Lou Z, Bozarth JM, Wu Y, Rendina A, Harper T, Zheng J, Xin B, Xiang Q, Luettgen JM, Seiffert DA, Wexler RR, Lam PYS.: Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorg Med Chem Lett, Volume 29 (19), 2019
Authors
Bozarth JM, Clark CG, Corte JR, De Lucca I, Ewing WR, Fang T, Harper T, Hu Z, Jeon Y, Lam PYS., Lou Z, Luettgen JM, Myers JE, Nirschl DS, Orwat MJ, Pinto DJP, Rendina A, Rossi KA, Seiffert DA, Sheriff S, Smallheer JM, Wang Y, Wexler RR, Wu Y, Xiang Q, Xin B, Yang W, Zheng J
Journal
Bioorg Med Chem Lett
Year
2019
PubMed
31445854
Machine-readable
REST APIRDF
Palacky University Olomouc

Palacky University Olomouc

Faculty of Science

Department of Physical Chemistry

tř. 17. listopadu 1192/12

771 46 Olomouc

Czech Republic

How to cite?

Juračka J., Šrejber M., Melíková M., Bazgier V., Berka K.: MolMeDB: Molecules on Membranes Database. Database, Volume 2019, 2019, baz078, https://doi.org/10.1093/database/baz078

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Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. | MolMeDB