Citation

Luo G, Chen L, Kostich WA, Hamman B, Allen J, Easton A, Bourin C, Gulianello M, Lippy J, Nara S, Maishal TK, Thiyagarajan K, Jalagam P, Pattipati SN, Dandapani K, Dokania M, Vattikundala P, Sharma V, Elavazhagan S, Verma MK, Das ML, Wagh S, Balakrishnan A, Johnson BM, Santone KS, Thalody G, Denton R, Saminathan H, Holenarsipur VK, Kumar A, Rao A, Putlur SP, Sarvasiddhi SK, Shankar G, Louis JV, Ramarao M, Conway CM, Li YW, Pieschl R, Tian Y, Hong Y, Ditta J, Mathur A, Li J, Smith D, Pawluczyk J, Sun D, Yip S, Wu DR, Vetrichelvan M, Gupta A, Wilson A, Gopinathan S, Wason S, Bristow L, Albright CF, Bronson JJ, Macor JE, Dzierba CD.: Discovery of (<i>S</i>)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem, Volume 65 (6), 2022

Authors

Albright CF, Allen J, Balakrishnan A, Bourin C, Bristow L, Bronson JJ, Chen L, Conway CM, Dandapani K, Das ML, Denton R, Ditta J, Dokania M, Dzierba CD., Easton A, Elavazhagan S, Gopinathan S, Gulianello M, Gupta A, Hamman B, Holenarsipur VK, Hong Y, Jalagam P, Johnson BM, Kostich WA, Kumar A, Li J, Li YW, Lippy J, Louis JV, Luo G, Macor JE, Maishal TK, Mathur A, Nara S, Pattipati SN, Pawluczyk J, Pieschl R, Putlur SP, Ramarao M, Rao A, Saminathan H, Santone KS, Sarvasiddhi SK, Shankar G, Sharma V, Smith D, Sun D, Thalody G, Thiyagarajan K, Tian Y, Vattikundala P, Verma MK, Vetrichelvan M, Wagh S, Wason S, Wilson A, Wu DR, Yip S

Journal

J Med Chem

Year

2022

DOI

10.1021/acs.jmedchem.1c02131

PubMed

35257579

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