Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.

Publication

Citation
Ramurthy S, Taft BR, Aversa RJ, Barsanti PA, Burger MT, Lou Y, Nishiguchi GA, Rico A, Setti L, Smith A, Subramanian S, Tamez V, Tanner H, Wan L, Hu C, Appleton BA, Mamo M, Tandeske L, Tellew JE, Huang S, Yue Q, Chaudhary A, Tian H, Iyer R, Hassan AQ, Mathews Griner LA, La Bonte LR, Cooke VG, Van Abbema A, Merritt H, Gampa K, Feng F, Yuan J, Mishina Y, Wang Y, Haling JR, Vaziri S, Hekmat-Nejad M, Polyakov V, Zang R, Sethuraman V, Amiri P, Singh M, Sellers WR, Lees E, Shao W, Dillon MP, Stuart DD.: Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic. J Med Chem, Volume 63 (5), 2020
Authors
Amiri P, Appleton BA, Aversa RJ, Barsanti PA, Burger MT, Chaudhary A, Cooke VG, Dillon MP, Feng F, Gampa K, Haling JR, Hassan AQ, Hekmat-Nejad M, Hu C, Huang S, Iyer R, La Bonte LR, Lees E, Lou Y, Mamo M, Mathews Griner LA, Merritt H, Mishina Y, Nishiguchi GA, Polyakov V, Ramurthy S, Rico A, Sellers WR, Sethuraman V, Setti L, Shao W, Singh M, Smith A, Stuart DD., Subramanian S, Taft BR, Tamez V, Tandeske L, Tanner H, Tellew JE, Tian H, van Abbema A, Vaziri S, Wan L, Wang Y, Yuan J, Yue Q, Zang R
Journal
J Med Chem
Year
2020
PubMed
31059256
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Palacky University Olomouc

Palacky University Olomouc

Faculty of Science

Department of Physical Chemistry

tř. 17. listopadu 1192/12

771 46 Olomouc

Czech Republic

How to cite?

Juračka J., Šrejber M., Melíková M., Bazgier V., Berka K.: MolMeDB: Molecules on Membranes Database. Database, Volume 2019, 2019, baz078, https://doi.org/10.1093/database/baz078

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  • MolMeDB interoperability with UniProt and SwissLipids – MEYS Czech-Swiss project ELIXIR-IMPACT 8K0208 (2026–2028)
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