Citation

Henry JR, Kaufman MD, Peng SB, Ahn YM, Caldwell TM, Vogeti L, Telikepalli H, Lu WP, Hood MM, Rutkoski TJ, Smith BD, Vogeti S, Miller D, Wise SC, Chun L, Zhang X, Zhang Y, Kays L, Hipskind PA, Wrobleski AD, Lobb KL, Clay JM, Cohen JD, Walgren JL, McCann D, Patel P, Clawson DK, Guo S, Manglicmot D, Groshong C, Logan C, Starling JJ, Flynn DL.: Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells. J Med Chem, Volume 58 (10), 2015

Authors

Ahn YM, Caldwell TM, Chun L, Clawson DK, Clay JM, Cohen JD, Flynn DL., Groshong C, Guo S, Henry JR, Hipskind PA, Hood MM, Kaufman MD, Kays L, Lobb KL, Logan C, Lu WP, Manglicmot D, McCann D, Miller D, Patel P, Peng SB, Rutkoski TJ, Smith BD, Starling JJ, Telikepalli H, Vogeti L, Vogeti S, Walgren JL, Wise SC, Wrobleski AD, Zhang X, Zhang Y

Journal

J Med Chem

Year

2015

DOI

10.1021/acs.jmedchem.5b00067

PubMed

25965804

Machine-readable

REST APIRDF