Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).

Citation: Come JH, Collier PN, Henderson JA, Pierce AC, Davies RJ, Le Tiran A, O'Dowd H, Bandarage UK, Cao J, Deininger D, Grey R, Krueger EB, Lowe DB, Liang J, Liao Y, Messersmith D, Nanthakumar S, Sizensky E, Wang J, Xu J, Chin EY, Damagnez V, Doran JD, Dworakowski W, Griffith JP, Jacobs MD, Khare-Pandit S, Mahajan S, Moody CS, Aronov AM.: Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS). J Med Chem, Volume 61 (12), 2018
Authors: Aronov AM., Bandarage UK, Cao J, Chin EY, Collier PN, Come JH, Damagnez V, Davies RJ, Deininger D, Doran JD, Dworakowski W, Grey R, Griffith JP, Henderson JA, Jacobs MD, Khare-Pandit S, Krueger EB, Le Tiran A, Liang J, Liao Y, Lowe DB, Mahajan S, Messersmith D, Moody CS, Nanthakumar S, O'Dowd H, Pierce AC, Sizensky E, Wang J, Xu J
Journal: J Med Chem
Year: 2018
DOI: 10.1021/acs.jmedchem.8b00085
PubMed: 29847724
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