- Citation
- Probst G, Aubele DL, Bowers S, Dressen D, Garofalo AW, Hom RK, Konradi AW, Marugg JL, Mattson MN, Neitzel ML, Semko CM, Sham HL, Smith J, Sun M, Truong AP, Ye XM, Xu YZ, Dappen MS, Jagodzinski JJ, Keim PS, Peterson B, Latimer LH, Quincy D, Wu J, Goldbach E, Ness DK, Quinn KP, Sauer JM, Wong K, Zhang H, Zmolek W, Brigham EF, Kholodenko D, Hu K, Kwong GT, Lee M, Liao A, Motter RN, Sacayon P, Santiago P, Willits C, Bard F, Bova MP, Hemphill SS, Nguyen L, Ruslim L, Tanaka K, Tanaka P, Wallace W, Yednock TA, Basi GS.: Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch. J Med Chem, Volume 56 (13), 2013
- Authors
- Aubele DL, Bard F, Basi GS., Bova MP, Bowers S, Brigham EF, Dappen MS, Dressen D, Garofalo AW, Goldbach E, Hemphill SS, Hom RK, Hu K, Jagodzinski JJ, Keim PS, Kholodenko D, Konradi AW, Kwong GT, Latimer LH, Lee M, Liao A, Marugg JL, Mattson MN, Motter RN, Neitzel ML, Ness DK, Nguyen L, Peterson B, Probst G, Quincy D, Quinn KP, Ruslim L, Sacayon P, Santiago P, Sauer JM, Semko CM, Sham HL, Smith J, Sun M, Tanaka K, Tanaka P, Truong AP, Wallace W, Willits C, Wong K, Wu J, Xu YZ, Ye XM, Yednock TA, Zhang H, Zmolek W
- Journal
- J Med Chem
- Year
- 2013
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