Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Citation: Scott JS, deSchoolmeester J, Kilgour E, Mayers RM, Packer MJ, Hargreaves D, Gerhardt S, Ogg DJ, Rees A, Selmi N, Stocker A, Swales JG, Whittamore PR.: Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem, Volume 55 (22), 2012
Authors: Deschoolmeester J, Gerhardt S, Hargreaves D, Kilgour E, Mayers RM, Ogg DJ, Packer MJ, Rees A, Scott JS, Selmi N, Stocker A, Swales JG, Whittamore PR.
Journal: J Med Chem
Year: 2012
DOI: 10.1021/jm301252n
PubMed: 23088558
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