Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent.

Citation: Van der Plas SE, Kelgtermans H, De Munck T, Martina SLX, Dropsit S, Quinton E, De Blieck A, Joannesse C, Tomaskovic L, Jans M, Christophe T, van der Aar E, Borgonovi M, Nelles L, Gees M, Stouten P, Van Der Schueren J, Mammoliti O, Conrath K, Andrews M.: Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem, Volume 61 (4), 2018
Authors: Andrews M., Borgonovi M, Christophe T, Conrath K, De Blieck A, De Munck T, Dropsit S, Gees M, Jans M, Joannesse C, Kelgtermans H, Mammoliti O, Martina SLX, Nelles L, Quinton E, Stouten P, Tomaskovic L, van der Aar E, Van der Plas SE, Van Der Schueren J
Journal: J Med Chem
Year: 2018
DOI: 10.1021/acs.jmedchem.7b01288
PubMed: 29148763
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