Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

Citation: Hirayama F, Koshio H, Ishihara T, Hachiya S, Sugasawa K, Koga Y, Seki N, Shiraki R, Shigenaga T, Iwatsuki Y, Moritani Y, Mori K, Kadokura T, Kawasaki T, Matsumoto Y, Sakamoto S, Tsukamoto S.: Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor. J Med Chem, Volume 54 (23), 2011
Authors: Hachiya S, Hirayama F, Ishihara T, Iwatsuki Y, Kadokura T, Kawasaki T, Koga Y, Koshio H, Matsumoto Y, Mori K, Moritani Y, Sakamoto S, Seki N, Shigenaga T, Shiraki R, Sugasawa K, Tsukamoto S.
Journal: J Med Chem
Year: 2011
DOI: 10.1021/jm200868m
PubMed: 21995444
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