Citation

Watterson SH, De Lucca GV, Shi Q, Langevine CM, Liu Q, Batt DG, Beaudoin Bertrand M, Gong H, Dai J, Yip S, Li P, Sun D, Wu DR, Wang C, Zhang Y, Traeger SC, Pattoli MA, Skala S, Cheng L, Obermeier MT, Vickery R, Discenza LN, D'Arienzo CJ, Zhang Y, Heimrich E, Gillooly KM, Taylor TL, Pulicicchio C, McIntyre KW, Galella MA, Tebben AJ, Muckelbauer JK, Chang C, Rampulla R, Mathur A, Salter-Cid L, Barrish JC, Carter PH, Fura A, Burke JR, Tino JA.: Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. J Med Chem, Volume 59 (19), 2016

Authors

Barrish JC, Batt DG, Beaudoin Bertrand M, Burke JR, Carter PH, Chang C, Cheng L, D'Arienzo CJ, Dai J, De Lucca GV, Discenza LN, Fura A, Galella MA, Gillooly KM, Gong H, Heimrich E, Langevine CM, Li P, Liu Q, Mathur A, McIntyre KW, Muckelbauer JK, Obermeier MT, Pattoli MA, Pulicicchio C, Rampulla R, Salter-Cid L, Shi Q, Skala S, Sun D, Taylor TL, Tebben AJ, Tino JA., Traeger SC, Vickery R, Wang C, Watterson SH, Wu DR, Yip S, Zhang Y

Journal

J Med Chem

Year

2016

DOI

10.1021/acs.jmedchem.6b01088

PubMed

27583770

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