Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Citation: Watterson SH, Chen P, Zhao Y, Gu HH, Dhar TG, Xiao Z, Ballentine SK, Shen Z, Fleener CA, Rouleau KA, Obermeier M, Yang Z, McIntyre KW, Shuster DJ, Witmer M, Dambach D, Chao S, Mathur A, Chen BC, Barrish JC, Robl JA, Townsend R, Iwanowicz EJ.: Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419). J Med Chem, Volume 50 (15), 2007
Authors: Ballentine SK, Barrish JC, Chao S, Chen BC, Chen P, Dambach D, Dhar TG, Fleener CA, Gu HH, Iwanowicz EJ., Mathur A, McIntyre KW, Obermeier M, Robl JA, Rouleau KA, Shen Z, Shuster DJ, Townsend R, Watterson SH, Witmer M, Xiao Z, Yang Z, Zhao Y
Journal: J Med Chem
Year: 2007
DOI: 10.1021/jm070299x
PubMed: 17585753
Machine-readable: REST API RDF

Publication