Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa.

Citation: Qiao JX, Cheney DL, Alexander RS, Smallwood AM, King SR, He K, Rendina AR, Luettgen JM, Knabb RM, Wexler RR, Lam PY.: Achieving structural diversity using the perpendicular conformation of alpha-substituted phenylcyclopropanes to mimic the bioactive conformation of ortho-substituted biphenyl P4 moieties: discovery of novel, highly potent inhibitors of Factor Xa. Bioorg Med Chem Lett, Volume 18 (14), 2008
Authors: Alexander RS, Cheney DL, He K, King SR, Knabb RM, Lam PY., Luettgen JM, Qiao JX, Rendina AR, Smallwood AM, Wexler RR
Journal: Bioorg Med Chem Lett
Year: 2008
DOI: 10.1016/j.bmcl.2008.05.095
PubMed: 18550370
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