Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia.

Citation: Chen C, Jiang W, Tucci F, Tran JA, Fleck BA, Hoare SR, Joppa M, Markison S, Wen J, Sai Y, Johns M, Madan A, Chen T, Chen CW, Marinkovic D, Arellano M, Saunders J, Foster AC.: Discovery of 1-[2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl]-4-[(2R)-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an orally active antagonist of the melanocortin-4 receptor for the potential treatment of cachexia. J Med Chem, Volume 50 (22), 2007
Authors: Arellano M, Chen C, Chen CW, Chen T, Fleck BA, Foster AC., Hoare SR, Jiang W, Johns M, Joppa M, Madan A, Marinkovic D, Markison S, Sai Y, Saunders J, Tran JA, Tucci F, Wen J
Journal: J Med Chem
Year: 2007
DOI: 10.1021/jm070806a
PubMed: 17918824
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