Citation

Baxter EW, Conway KA, Kennis L, Bischoff F, Mercken MH, Winter HL, Reynolds CH, Tounge BA, Luo C, Scott MK, Huang Y, Braeken M, Pieters SM, Berthelot DJ, Masure S, Bruinzeel WD, Jordan AD, Parker MH, Boyd RE, Qu J, Alexander RS, Brenneman DE, Reitz AB.: 2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. J Med Chem, Volume 50 (18), 2007

Authors

Alexander RS, Baxter EW, Berthelot DJ, Bischoff F, Boyd RE, Braeken M, Brenneman DE, Bruinzeel WD, Conway KA, Huang Y, Jordan AD, Kennis L, Luo C, Masure S, Mercken MH, Parker MH, Pieters SM, Qu J, Reitz AB., Reynolds CH, Scott MK, Tounge BA, Winter HL

Journal

J Med Chem

Year

2007

DOI

10.1021/jm0705408

PubMed

17685503

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