Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.

Citation: Wang T, Yin Z, Zhang Z, Bender JA, Yang Z, Johnson G, Yang Z, Zadjura LM, D'Arienzo CJ, DiGiugno Parker D, Gesenberg C, Yamanaka GA, Gong YF, Ho HT, Fang H, Zhou N, McAuliffe BV, Eggers BJ, Fan L, Nowicka-Sans B, Dicker IB, Gao Q, Colonno RJ, Lin PF, Meanwell NA, Kadow JF.: Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects. J Med Chem, Volume 52 (23), 2009
Authors: Bender JA, Colonno RJ, D'Arienzo CJ, Dicker IB, DiGiugno Parker D, Eggers BJ, Fan L, Fang H, Gao Q, Gesenberg C, Gong YF, Ho HT, Johnson G, Kadow JF., Lin PF, McAuliffe BV, Meanwell NA, Nowicka-Sans B, Wang T, Yamanaka GA, Yang Z, Yin Z, Zadjura LM, Zhang Z, Zhou N
Journal: J Med Chem
Year: 2009
DOI: 10.1021/jm900843g
PubMed: 19769332
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