Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities.

Citation: Annedi SC, Ramnauth J, Maddaford SP, Renton P, Rakhit S, Mladenova G, Dove P, Silverman S, Andrews JS, Felice MD, Porreca F.: Discovery of cis-N-(1-(4-(methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: a 1,6-disubstituted indoline derivative as a highly selective inhibitor of human neuronal nitric oxide synthase (nNOS) without any cardiovascular liabilities. J Med Chem, Volume 55 (2), 2012
Authors: Andrews JS, Annedi SC, Dove P, Felice MD, Maddaford SP, Mladenova G, Porreca F., Rakhit S, Ramnauth J, Renton P, Silverman S
Journal: J Med Chem
Year: 2012
DOI: 10.1021/jm201564u
PubMed: 22175766
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