Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Citation: Hayashi S, Nakata E, Morita A, Mizuno K, Yamamura K, Kato A, Ohashi K.: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships. Bioorg Med Chem, Volume 18 (21), 2010
Authors: Hayashi S, Kato A, Mizuno K, Morita A, Nakata E, Ohashi K., Yamamura K
Journal: Bioorg Med Chem
Year: 2010
DOI: 10.1016/j.bmc.2010.07.034
PubMed: 20875743
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