L-Tyrosine | MolMeDB

L-Tyrosine

2D Structure

3D Structure

Source:

General
Identifier	MM00760
SMILES	N[C@@H](Cc1ccc(O)cc1)C(=O)O Presented in the original dataset.
InChIKey	OUYCCCASQSFEME-QMMMGPOBSA-N Automatically obtained from RDkit software.
MW [Da]	181.19 Automatically obtained from RDkit software.
LogP	0.35 Automatically obtained from RDkit software.

Links
PubChem	6057 Presented in the original dataset.
DrugBank	DB00135 Presented in the original dataset.
ChEBI	58315 Presented in the original dataset.
PDB	TYR Presented in the original dataset.
ChEMBL	CHEMBL925 Presented in the original dataset.

Similar entries

L-alpha-methyltyrosine

Similarity: 0.8262

Similarity to L-alpha-methyltyrosine

Tanimoto metric	0.8262
Cosine metric	0.909
Dice metric	0.9049

Total passive interactions

L-Tyrosine	4
L-alpha-methyltyrosine	1

Total active interactions

L-Tyrosine	1
L-alpha-methyltyrosine	1

L-Phenylalanine

Similarity: 0.8155

Similarity to L-Phenylalanine

Tanimoto metric	0.8155
Cosine metric	0.903
Dice metric	0.8983

Total passive interactions

L-Tyrosine	4
L-Phenylalanine	13

Total active interactions

L-Tyrosine	1
L-Phenylalanine	1

D-phenylalanine

Similarity: 0.8155

Similarity to D-phenylalanine

Tanimoto metric	0.8155
Cosine metric	0.903
Dice metric	0.8983

Total passive interactions

L-Tyrosine	4
D-phenylalanine	0

Total active interactions

L-Tyrosine	1
D-phenylalanine	1

+25 more

No data

Methods

Computed

Mechanistic

Q-based

QSAR

No data

Target	Uniprot ID	Type	pKm	pEC₅₀	pK_i	pIC₅₀	Primary reference	Secondary reference	Note
Hide empty columns:
SLC7A5	Q01650	Non-inhibitor				4.17	Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA.: Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem, Volume 61 (16), 2018 Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA.: Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1). J Med Chem, Volume 61 (16), 2018	Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR.: The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res, Volume 52 (d1), D1180-D1192, 2024 Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR.: The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res, Volume 52 (d1), D1180-D1192, 2024

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