substance;substance_identifier;membrane;method;charge;temperature;note;x_min;x_min_acc;g_pen;g_pen_acc;g_wat;g_wat_acc;log_k;log_k_acc;log_perm;log_perm_acc;primary_publication;secondary_publication
Sucrose;MM00421;DMPC;CCM15;0;25;;3.153;;16.441;;0.717;;-11.683;;;;;"in-house calculations"
Sucrose;MM00421;DOPC;CCM15;0;25;;3.629;;16.119;;0.886;;-5.477;;;;;"in-house calculations"
Sucrose;MM00421;"SC mix";CCM15;0;25;;3.836;;17.225;;1.13;;-5.027;;;;;"in-house calculations"
Sucrose;MM00421;CACO;ECACO;0;37;;;;;;;;;;-5.77;;;"Yazdanian M, Glynn SL, Wright JL, Hawi A.: Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds. Pharm Res, Volume 15 (9), 1490-1494, 1998"
Sucrose;MM00421;DOPC;CCM18;0;25;;3.63;;18.82;;1.52;;-5.48;;-13.16;;;"in-house calculations"
Sucrose;MM00421;"EYE-Sclera ";EFDC;;33;;;;;;;;;;-4.38;;;"Ahmed I, Gokhale RD, Shah MV, Patton TF.: Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea. J Pharm Sci, Volume 76 (8), 583-586, 1987"
Sucrose;MM00421;"EYE-Sclera ";EUC;;37;;;;;;;;;;-4.66;;;"Olsen T. W., Edelhauser H. F., Lim J. I., Geroski D. H.: Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Invest. Ophthalmol. Vis. Sci., 36, 1893–1903,1995."
Sucrose;MM00421;EYE-Endothelium;EPS;;34;;;;;;;;;;-5.19;;;"Mishima S., Trenberth S. M.: Permeability of the Corneal Endothelium to Nonelectrolytes. Investigative Ophthalmol. Vis. Sci., 7, 34–43, 1968."
Sucrose;MM00421;EYE-Endothelium;EPS;;36;;;;;;;;;;-5.25;;;"Riley M. V.: A study of the transfer of amino acids across the endothelium of the rabbit cornea. Exp. Eye Res., 24, 35–44,1977."
Sucrose;MM00421;Caco2/MDCK;CPapp;0;37;;;;;;;;;;-5.94692;;;"Bittermann K, Goss KU.: Predicting apparent passive permeability of Caco-2 and MDCK cell-monolayers: A mechanistic model. PLoS One, Volume 12 (12), e0190319, 2017"
Sucrose;MM00421;CACO;QSAR-PSA;;25;;;;;;;;;;-6.412;;;"Subramanian G, Kitchen DB.: Computational approaches for modeling human intestinal absorption and permeability. J Mol Model, Volume 12 (5), 577-589, 2006"
Sucrose;MM00421;CACO;QSAR-HB;;25;;;;;;;;;;-7.691;;;"Subramanian G, Kitchen DB.: Computational approaches for modeling human intestinal absorption and permeability. J Mol Model, Volume 12 (5), 577-589, 2006"
Sucrose;MM00421;1-octanol;XLOGP3;;;;;;;;;;-3.7;;;;;"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE.: PubChem 2023 update. Nucleic Acids Res, Volume 51 (d1), D1373-D1380, 2023"
Sucrose;MM00421;EggPC;ELIP;;25;"pH=7.5, LUV";;;;;;;;;-13.1;;;"Lomize AL, Pogozheva ID: Prediction of passive membrane permeability and translocation pathways of biologically active molecules. Biophys. J., 112(3) Supp1, 525a., 2017."
Sucrose;MM00421;LEC;CPMM;0;25;"<a href=https://permm.phar.umich.edu/  target=_blank>PerMM web server</a>";;;;;;;;;-15.91;;;"Lomize AL,Hage JM, Schnitzer K, Golobokov K, LaFaive MB, Forsyth AC, Pogozheva ID: PerMM: A Web Tool and Database for Analysis of Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules. J. Chem. Inf. Model. 59(7), 3094-3099, 2019"
Sucrose;MM00421;LEC;CPMM;0;25;"pH=7.4 ,<a href=https://permm.phar.umich.edu/  target=_blank>PerMM web server</a>";;;;;;;;;-15.91;;;"Lomize AL,Hage JM, Schnitzer K, Golobokov K, LaFaive MB, Forsyth AC, Pogozheva ID: PerMM: A Web Tool and Database for Analysis of Passive Membrane Permeability and Translocation Pathways of Bioactive Molecules. J. Chem. Inf. Model. 59(7), 3094-3099, 2019"
Sucrose;MM00421;CACO;ECACO;0;25;"<a href=https://pubchem.ncbi.nlm.nih.gov/bioassay/455986  target=_blank>455986</a>";;;;;;;;;-5.77;;;"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S, Li Q, Shoemaker BA, Thiessen PA, Yu B, Zaslavsky L, Zhang J, Bolton EE.: PubChem 2023 update. Nucleic Acids Res, Volume 51 (d1), D1373-D1380, 2023"
Sucrose;MM00421;CACO;ECACO;;37;"pH 7,2";;;;;;;;;-5.85;;;"Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, Hurst RD, Lindmark T, Mabondzo A, Nilsson JE, Raub TJ, Stanimirovic D, Terasaki T, Oberg JO, Osterberg T. In vitro models for the blood-brain barrier. Toxicol In Vitro. 2005 Apr;19(3):299-334."
Sucrose;MM00421;MDCK;EMDCK;;37;"pH 7,2";;;;;;;;;-6.7;;;"Garberg P, Ball M, Borg N, Cecchelli R, Fenart L, Hurst RD, Lindmark T, Mabondzo A, Nilsson JE, Raub TJ, Stanimirovic D, Terasaki T, Oberg JO, Osterberg T. In vitro models for the blood-brain barrier. Toxicol In Vitro. 2005 Apr;19(3):299-334."