substance;substance_identifier;target;type;note;Km;Km_acc;EC50;EC50_acc;Ki;Ki_acc;IC50;IC50_acc;primary_publication;secondary_publication
Dextroamphetamine;MM16720;SLC6A2;Inhibitor;;;;;;7;;;;"Tatsumi M, Groshan K, Blakely RD, Richelson E.: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol, Volume 340 (2-3), 1997";"Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA.: The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Res, Volume 52 (d1), D1438-D1449, 2024"
Dextroamphetamine;MM16720;SLC6A3;Inhibitor;;;;;;7;;;;"Lapinsky DJ, Velagaleti R, Yarravarapu N, Liu Y, Huang Y, Surratt CK, Lever JR, Foster JD, Acharya R, Vaughan RA, Deutsch HM.: Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling. Bioorg Med Chem, Volume 19 (1), 2011";"Harding SD, Armstrong JF, Faccenda E, Southan C, Alexander SPH, Davenport AP, Spedding M, Davies JA.: The IUPHAR/BPS Guide to PHARMACOLOGY in 2024. Nucleic Acids Res, Volume 52 (d1), D1438-D1449, 2024"
Dextroamphetamine;MM16720;SLC22A1;Non-inhibitor;;;;;;;;3.69;;"Koepsell H, Lips K, Volk C.: Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res, Volume 24 (7), 2007";"Mak L, Marcus D, Howlett A, Yarova G, Duchateau G, Klaffke W, Bender A, Glen RC.: Metrabase: a cheminformatics and bioinformatics database for small molecule transporter data analysis and (Q)SAR modeling. J Cheminform, Volume 7, 31, 2015"
Dextroamphetamine;MM16720;SLC6A2;Substrate;;;;8.15;;;;;;"Lewin AH, Miller GM, Gilmour B.: Trace amine-associated receptor 1 is a stereoselective binding site for compounds in the amphetamine class. Bioorg Med Chem, Volume 19 (23), 2011";"Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR.: The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res, Volume 52 (d1), D1180-D1192, 2024"
Dextroamphetamine;MM16720;SLC6A2;Inhibitor;;;;;;;;6.2;;"Arunotayanun W, Dalley JW, Huang XP, Setola V, Treble R, Iversen L, Roth BL, Gibbons S.: An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorg Med Chem Lett, Volume 23 (11), 2013";"Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR.: The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res, Volume 52 (d1), D1180-D1192, 2024"
Dextroamphetamine;MM16720;SLC6A4;Non-inhibitor;;;;;;;;4.78;;"Arunotayanun W, Dalley JW, Huang XP, Setola V, Treble R, Iversen L, Roth BL, Gibbons S.: An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'. Bioorg Med Chem Lett, Volume 23 (11), 2013";"Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR.: The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res, Volume 52 (d1), D1180-D1192, 2024"