{"data":{"id":5050,"citation":"Akula RK, El Kilani H, Metzen A, R\u00f6ske J, Zhang K, G\u00f6hl M, Arisetti N, Marsh GP, Maple HJ, Cooper MS, Karadogan B, Jochmans D, Neyts J, Rox K, Hilgenfeld R, Br\u00f6nstrup M.: Structure-Based Optimization of Pyridone \u03b1-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.. Journal of medicinal chemistry, Volume 68 (3), 2920-2941, 2025","title":"Structure-Based Optimization of Pyridone \u03b1-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease.","doi":"10.1021\/acs.jmedchem.4c02172","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.4c02172","pmid":"39817813","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/39817813\/","year":2025,"journal":"Journal of medicinal chemistry","volume":"68","issue":"3","page":"2920-2941","authors":[{"first_name":"Ravi Kumar","last_name":"Akula","full_name":"Akula RK"},{"first_name":"Haifa","last_name":"El Kilani","full_name":"El Kilani H"},{"first_name":"Alina","last_name":"Metzen","full_name":"Metzen A"},{"first_name":"Judith","last_name":"R\u00f6ske","full_name":"R\u00f6ske J"},{"first_name":"Kaixuan","last_name":"Zhang","full_name":"Zhang K"},{"first_name":"Matthias","last_name":"G\u00f6hl","full_name":"G\u00f6hl M"},{"first_name":"Nanaji","last_name":"Arisetti","full_name":"Arisetti N"},{"first_name":"Graham P","last_name":"Marsh","full_name":"Marsh GP"},{"first_name":"Hannah J","last_name":"Maple","full_name":"Maple HJ"},{"first_name":"Mark S","last_name":"Cooper","full_name":"Cooper MS"},{"first_name":"Burhan","last_name":"Karadogan","full_name":"Karadogan B"},{"first_name":"Dirk","last_name":"Jochmans","full_name":"Jochmans D"},{"first_name":"Johan","last_name":"Neyts","full_name":"Neyts J"},{"first_name":"Katharina","last_name":"Rox","full_name":"Rox K"},{"first_name":"Rolf","last_name":"Hilgenfeld","full_name":"Hilgenfeld R"},{"first_name":"Mark","last_name":"Br\u00f6nstrup","full_name":"Br\u00f6nstrup M"}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/5050","landing_page":"https:\/\/molmedb.upol.cz\/publication\/5050","created_at":"2026-07-13T17:59:19.000000Z","updated_at":"2026-07-13T17:59:19.000000Z"}}