{"data":{"id":4804,"citation":"Stepan A., Subramanyam C., Efremov I., Dutra J., O\u2019Sullivan T., DiRico K., McDonald W., Won A., Dorff P., Nolan C., Becker S., Pustilnik L., Riddell D., Kauffman G., Kormos B., Zhang L., Lu Y., Capetta S., Green M., Karki K., Sibley E., Atchison K., Hallgren A., Oborski C., Robshaw A., Sneed B., O\u2019Donnell C.: Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active \u03b3-Secretase Inhibitor. Journal of Medicinal Chemistry, Volume 55 (7), 2012","title":"Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active \u03b3-Secretase Inhibitor","doi":"10.1021\/jm300094u","doi_url":"https:\/\/doi.org\/10.1021\/jm300094u","pmid":null,"year":2012,"journal":"Journal of Medicinal Chemistry","volume":"55","issue":"7","page":null,"authors":[{"first_name":"Antonia F.","last_name":"Stepan","full_name":"Antonia F. Stepan"},{"first_name":"Chakrapani","last_name":"Subramanyam","full_name":"Chakrapani Subramanyam"},{"first_name":"Ivan V.","last_name":"Efremov","full_name":"Ivan V. Efremov"},{"first_name":"Jason K.","last_name":"Dutra","full_name":"Jason K. Dutra"},{"first_name":"Theresa J.","last_name":"O\u2019Sullivan","full_name":"Theresa J. O\u2019Sullivan"},{"first_name":"Kenneth J.","last_name":"DiRico","full_name":"Kenneth J. DiRico"},{"first_name":"W. Scott","last_name":"McDonald","full_name":"W. Scott McDonald"},{"first_name":"Annie","last_name":"Won","full_name":"Annie Won"},{"first_name":"Peter H.","last_name":"Dorff","full_name":"Peter H. Dorff"},{"first_name":"Charles E.","last_name":"Nolan","full_name":"Charles E. Nolan"},{"first_name":"Stacey L.","last_name":"Becker","full_name":"Stacey L. Becker"},{"first_name":"Leslie R.","last_name":"Pustilnik","full_name":"Leslie R. Pustilnik"},{"first_name":"David R.","last_name":"Riddell","full_name":"David R. Riddell"},{"first_name":"Gregory W.","last_name":"Kauffman","full_name":"Gregory W. Kauffman"},{"first_name":"Bethany L.","last_name":"Kormos","full_name":"Bethany L. Kormos"},{"first_name":"Liming","last_name":"Zhang","full_name":"Liming Zhang"},{"first_name":"Yasong","last_name":"Lu","full_name":"Yasong Lu"},{"first_name":"Steven H.","last_name":"Capetta","full_name":"Steven H. Capetta"},{"first_name":"Michael E.","last_name":"Green","full_name":"Michael E. Green"},{"first_name":"Kapil","last_name":"Karki","full_name":"Kapil Karki"},{"first_name":"Evelyn","last_name":"Sibley","full_name":"Evelyn Sibley"},{"first_name":"Kevin P.","last_name":"Atchison","full_name":"Kevin P. Atchison"},{"first_name":"Andrew J.","last_name":"Hallgren","full_name":"Andrew J. Hallgren"},{"first_name":"Christine E.","last_name":"Oborski","full_name":"Christine E. Oborski"},{"first_name":"Ashley E.","last_name":"Robshaw","full_name":"Ashley E. Robshaw"},{"first_name":"Blossom","last_name":"Sneed","full_name":"Blossom Sneed"},{"first_name":"Christopher J.","last_name":"O\u2019Donnell","full_name":"Christopher J. O\u2019Donnell"}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4804","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4804","created_at":"2026-06-22T14:34:53.000000Z","updated_at":"2026-06-22T14:34:53.000000Z"}}