{"data":{"id":4799,"citation":"Lee K., Ambler C., Anderson D., Boscoe B., Bree A., Brodfuehrer J., Chang J., Choi C., Chung S., Curran K., Day J., Dehnhardt C., Dower K., Drozda S., Frisbie R., Gavrin L., Goldberg J., Han S., Hegen M., Hepworth D., Hope H., Kamtekar S., Kilty I., Lee A., Lin L., Lovering F., Lowe M., Mathias J., Morgan H., Murphy E., Papaioannou N., Patny A., Pierce B., Rao V., Saiah E., Samardjiev I., Samas B., Shen M., Shin J., Soutter H., Strohbach J., Symanowicz P., Thomason J., Trzupek J., Vargas R., Vincent F., Yan J., Zapf C., Wright S.: Discovery of Clinical Candidate 1-{[(2\n                    <i>S<\/i>\n                    ,3\n                    <i>S<\/i>\n                    ,4\n                    <i>S<\/i>\n                    )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. Journal of Medicinal Chemistry, Volume 60 (13), 2017","title":"Discovery of Clinical Candidate 1-{[(2\n                    <i>S<\/i>\n                    ,3\n                    <i>S<\/i>\n                    ,4\n                    <i>S<\/i>\n                    )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design","doi":"10.1021\/acs.jmedchem.7b00231","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.7b00231","pmid":null,"year":2017,"journal":"Journal of Medicinal Chemistry","volume":"60","issue":"13","page":null,"authors":[{"first_name":"Katherine L.","last_name":"Lee","full_name":"Katherine L. Lee"},{"first_name":"Catherine M.","last_name":"Ambler","full_name":"Catherine M. Ambler"},{"first_name":"David R.","last_name":"Anderson","full_name":"David R. Anderson"},{"first_name":"Brian P.","last_name":"Boscoe","full_name":"Brian P. Boscoe"},{"first_name":"Andrea G.","last_name":"Bree","full_name":"Andrea G. Bree"},{"first_name":"Joanne I.","last_name":"Brodfuehrer","full_name":"Joanne I. Brodfuehrer"},{"first_name":"Jeanne S.","last_name":"Chang","full_name":"Jeanne S. Chang"},{"first_name":"Chulho","last_name":"Choi","full_name":"Chulho Choi"},{"first_name":"Seungwon","last_name":"Chung","full_name":"Seungwon Chung"},{"first_name":"Kevin J.","last_name":"Curran","full_name":"Kevin J. Curran"},{"first_name":"Jacqueline E.","last_name":"Day","full_name":"Jacqueline E. Day"},{"first_name":"Christoph M.","last_name":"Dehnhardt","full_name":"Christoph M. Dehnhardt"},{"first_name":"Ken","last_name":"Dower","full_name":"Ken Dower"},{"first_name":"Susan E.","last_name":"Drozda","full_name":"Susan E. Drozda"},{"first_name":"Richard K.","last_name":"Frisbie","full_name":"Richard K. Frisbie"},{"first_name":"Lori K.","last_name":"Gavrin","full_name":"Lori K. Gavrin"},{"first_name":"Joel A.","last_name":"Goldberg","full_name":"Joel A. Goldberg"},{"first_name":"Seungil","last_name":"Han","full_name":"Seungil Han"},{"first_name":"Martin","last_name":"Hegen","full_name":"Martin Hegen"},{"first_name":"David","last_name":"Hepworth","full_name":"David Hepworth"},{"first_name":"Heidi R.","last_name":"Hope","full_name":"Heidi R. Hope"},{"first_name":"Satwik","last_name":"Kamtekar","full_name":"Satwik Kamtekar"},{"first_name":"Iain C.","last_name":"Kilty","full_name":"Iain C. Kilty"},{"first_name":"Arthur","last_name":"Lee","full_name":"Arthur Lee"},{"first_name":"Lih-Ling","last_name":"Lin","full_name":"Lih-Ling Lin"},{"first_name":"Frank E.","last_name":"Lovering","full_name":"Frank E. Lovering"},{"first_name":"Michael D.","last_name":"Lowe","full_name":"Michael D. Lowe"},{"first_name":"John P.","last_name":"Mathias","full_name":"John P. Mathias"},{"first_name":"Heidi M.","last_name":"Morgan","full_name":"Heidi M. Morgan"},{"first_name":"Elizabeth A.","last_name":"Murphy","full_name":"Elizabeth A. Murphy"},{"first_name":"Nikolaos","last_name":"Papaioannou","full_name":"Nikolaos Papaioannou"},{"first_name":"Akshay","last_name":"Patny","full_name":"Akshay Patny"},{"first_name":"Betsy S.","last_name":"Pierce","full_name":"Betsy S. Pierce"},{"first_name":"Vikram R.","last_name":"Rao","full_name":"Vikram R. Rao"},{"first_name":"Eddine","last_name":"Saiah","full_name":"Eddine Saiah"},{"first_name":"Ivan J.","last_name":"Samardjiev","full_name":"Ivan J. Samardjiev"},{"first_name":"Brian M.","last_name":"Samas","full_name":"Brian M. Samas"},{"first_name":"Marina W. H.","last_name":"Shen","full_name":"Marina W. H. Shen"},{"first_name":"Julia H.","last_name":"Shin","full_name":"Julia H. Shin"},{"first_name":"Holly H.","last_name":"Soutter","full_name":"Holly H. Soutter"},{"first_name":"Joseph W.","last_name":"Strohbach","full_name":"Joseph W. Strohbach"},{"first_name":"Peter T.","last_name":"Symanowicz","full_name":"Peter T. Symanowicz"},{"first_name":"Jennifer R.","last_name":"Thomason","full_name":"Jennifer R. Thomason"},{"first_name":"John D.","last_name":"Trzupek","full_name":"John D. Trzupek"},{"first_name":"Richard","last_name":"Vargas","full_name":"Richard Vargas"},{"first_name":"Fabien","last_name":"Vincent","full_name":"Fabien Vincent"},{"first_name":"Jiangli","last_name":"Yan","full_name":"Jiangli Yan"},{"first_name":"Christoph W.","last_name":"Zapf","full_name":"Christoph W. Zapf"},{"first_name":"Stephen W.","last_name":"Wright","full_name":"Stephen W. Wright"}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4799","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4799","created_at":"2026-06-22T14:34:41.000000Z","updated_at":"2026-06-22T14:34:41.000000Z"}}