{"data":{"id":4790,"citation":"Pettersson M., Johnson D., Humphrey J., Butler T., am Ende C., Fish B., Green M., Kauffman G., Mullins P., O\u2019Donnell C., Stepan A., Stiff C., Subramanyam C., Tran T., Vetelino B., Yang E., Xie L., Bales K., Pustilnik L., Steyn S., Wood K., Verhoest P.: Design of Pyridopyrazine-1,6-dione \u03b3-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. ACS Medicinal Chemistry Letters, Volume 6 (5), 2015","title":"Design of Pyridopyrazine-1,6-dione \u03b3-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability","doi":"10.1021\/acsmedchemlett.5b00070","doi_url":"https:\/\/doi.org\/10.1021\/acsmedchemlett.5b00070","pmid":null,"year":2015,"journal":"ACS Medicinal Chemistry Letters","volume":"6","issue":"5","page":null,"authors":[{"first_name":"Martin","last_name":"Pettersson","full_name":"Martin Pettersson"},{"first_name":"Douglas S.","last_name":"Johnson","full_name":"Douglas S. Johnson"},{"first_name":"John M.","last_name":"Humphrey","full_name":"John M. Humphrey"},{"first_name":"Todd W.","last_name":"Butler","full_name":"Todd W. Butler"},{"first_name":"Christopher W.","last_name":"am Ende","full_name":"Christopher W. am Ende"},{"first_name":"Benjamin A.","last_name":"Fish","full_name":"Benjamin A. Fish"},{"first_name":"Michael E.","last_name":"Green","full_name":"Michael E. Green"},{"first_name":"Gregory W.","last_name":"Kauffman","full_name":"Gregory W. Kauffman"},{"first_name":"Patrick B.","last_name":"Mullins","full_name":"Patrick B. Mullins"},{"first_name":"Christopher J.","last_name":"O\u2019Donnell","full_name":"Christopher J. O\u2019Donnell"},{"first_name":"Antonia F.","last_name":"Stepan","full_name":"Antonia F. Stepan"},{"first_name":"Cory M.","last_name":"Stiff","full_name":"Cory M. Stiff"},{"first_name":"Chakrapani","last_name":"Subramanyam","full_name":"Chakrapani Subramanyam"},{"first_name":"Tuan P.","last_name":"Tran","full_name":"Tuan P. Tran"},{"first_name":"Beth Cooper","last_name":"Vetelino","full_name":"Beth Cooper Vetelino"},{"first_name":"Eddie","last_name":"Yang","full_name":"Eddie Yang"},{"first_name":"Longfei","last_name":"Xie","full_name":"Longfei Xie"},{"first_name":"Kelly R.","last_name":"Bales","full_name":"Kelly R. Bales"},{"first_name":"Leslie R.","last_name":"Pustilnik","full_name":"Leslie R. Pustilnik"},{"first_name":"Stefanus J.","last_name":"Steyn","full_name":"Stefanus J. Steyn"},{"first_name":"Kathleen M.","last_name":"Wood","full_name":"Kathleen M. Wood"},{"first_name":"Patrick R.","last_name":"Verhoest","full_name":"Patrick R. Verhoest"}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4790","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4790","created_at":"2026-06-22T14:33:06.000000Z","updated_at":"2026-06-22T14:33:06.000000Z"}}