{"data":{"id":4113,"citation":"Phillips DP, Gao W, Yang Y, Zhang G, Lerario IK, Lau TL, Jiang J, Wang X, Nguyen DG, Bhat BG, Trotter C, Sullivan H, Welzel G, Landry J, Chen Y, Joseph SB, Li C, Gordon WP, Richmond W, Johnson K, Bretz A, Bursulaya B, Pan S, McNamara P, Seidel HM.: Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem, Volume 57 (8), 2014","title":"Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.","doi":"10.1021\/jm401731q","doi_url":"https:\/\/doi.org\/10.1021\/jm401731q","pmid":"24666203","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/24666203\/","year":2014,"journal":"J Med Chem","volume":"57","issue":"8","page":"3263-3282","authors":[{"first_name":"Bhat BG","last_name":null,"full_name":null},{"first_name":"Bretz A","last_name":null,"full_name":null},{"first_name":"Bursulaya B","last_name":null,"full_name":null},{"first_name":"Chen Y","last_name":null,"full_name":null},{"first_name":"Gao W","last_name":null,"full_name":null},{"first_name":"Gordon WP","last_name":null,"full_name":null},{"first_name":"Jiang J","last_name":null,"full_name":null},{"first_name":"Johnson K","last_name":null,"full_name":null},{"first_name":"Joseph SB","last_name":null,"full_name":null},{"first_name":"Landry J","last_name":null,"full_name":null},{"first_name":"Lau TL","last_name":null,"full_name":null},{"first_name":"Lerario IK","last_name":null,"full_name":null},{"first_name":"Li C","last_name":null,"full_name":null},{"first_name":"McNamara P","last_name":null,"full_name":null},{"first_name":"Nguyen DG","last_name":null,"full_name":null},{"first_name":"Pan S","last_name":null,"full_name":null},{"first_name":"Phillips DP","last_name":null,"full_name":null},{"first_name":"Richmond W","last_name":null,"full_name":null},{"first_name":"Seidel HM.","last_name":null,"full_name":null},{"first_name":"Sullivan H","last_name":null,"full_name":null},{"first_name":"Trotter C","last_name":null,"full_name":null},{"first_name":"Wang X","last_name":null,"full_name":null},{"first_name":"Welzel G","last_name":null,"full_name":null},{"first_name":"Yang Y","last_name":null,"full_name":null},{"first_name":"Zhang G","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4113","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4113","created_at":"2024-05-21T20:15:09.000000Z","updated_at":null}}