{"data":{"id":4045,"citation":"Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G.: A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660). J Med Chem, Volume 61 (16), 2018","title":"A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).","doi":"10.1021\/acs.jmedchem.8b00900","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.8b00900","pmid":"30091600","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/30091600\/","year":2018,"journal":"J Med Chem","volume":"61","issue":"16","page":"7314-7329","authors":[{"first_name":"Ahn JS","last_name":null,"full_name":null},{"first_name":"Buck IM","last_name":null,"full_name":null},{"first_name":"Chessari G.","last_name":null,"full_name":null},{"first_name":"Chiarparin E","last_name":null,"full_name":null},{"first_name":"Day JEH","last_name":null,"full_name":null},{"first_name":"Hopkins A","last_name":null,"full_name":null},{"first_name":"Howard S","last_name":null,"full_name":null},{"first_name":"Johnson CN","last_name":null,"full_name":null},{"first_name":"Lewis EJ","last_name":null,"full_name":null},{"first_name":"Martins V","last_name":null,"full_name":null},{"first_name":"Millemaggi A","last_name":null,"full_name":null},{"first_name":"Munck JM","last_name":null,"full_name":null},{"first_name":"Page LW","last_name":null,"full_name":null},{"first_name":"Peakman T","last_name":null,"full_name":null},{"first_name":"Reader M","last_name":null,"full_name":null},{"first_name":"Rich SJ","last_name":null,"full_name":null},{"first_name":"Saxty G","last_name":null,"full_name":null},{"first_name":"Smyth T","last_name":null,"full_name":null},{"first_name":"Thompson NT","last_name":null,"full_name":null},{"first_name":"Ward GA","last_name":null,"full_name":null},{"first_name":"Williams PA","last_name":null,"full_name":null},{"first_name":"Wilsher NE","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4045","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4045","created_at":"2024-05-21T20:14:47.000000Z","updated_at":null}}