{"data":{"id":4032,"citation":"Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T.: Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915). J Med Chem, Volume 58 (4), 2015","title":"Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).","doi":"10.1021\/jm501185j","doi_url":"https:\/\/doi.org\/10.1021\/jm501185j","pmid":"25671290","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/25671290\/","year":2015,"journal":"J Med Chem","volume":"58","issue":"4","page":"1669-1690","authors":[{"first_name":"Abeywardane A","last_name":null,"full_name":null},{"first_name":"Bartolozzi A","last_name":null,"full_name":null},{"first_name":"Berger V","last_name":null,"full_name":null},{"first_name":"Binetti R","last_name":null,"full_name":null},{"first_name":"Bosanac T","last_name":null,"full_name":null},{"first_name":"Broadwater J","last_name":null,"full_name":null},{"first_name":"Chen Z","last_name":null,"full_name":null},{"first_name":"Crux R","last_name":null,"full_name":null},{"first_name":"Dave R","last_name":null,"full_name":null},{"first_name":"De Lombaert S","last_name":null,"full_name":null},{"first_name":"Dines JA","last_name":null,"full_name":null},{"first_name":"Fadra-Khan T","last_name":null,"full_name":null},{"first_name":"Flegg A","last_name":null,"full_name":null},{"first_name":"Garrigou M","last_name":null,"full_name":null},{"first_name":"Hao MH","last_name":null,"full_name":null},{"first_name":"Huber J","last_name":null,"full_name":null},{"first_name":"Hutzler JM","last_name":null,"full_name":null},{"first_name":"Kerr S","last_name":null,"full_name":null},{"first_name":"Kotey A","last_name":null,"full_name":null},{"first_name":"Liu W","last_name":null,"full_name":null},{"first_name":"Lo HY","last_name":null,"full_name":null},{"first_name":"Loke PL","last_name":null,"full_name":null},{"first_name":"Mahaney PE","last_name":null,"full_name":null},{"first_name":"Morwick TM","last_name":null,"full_name":null},{"first_name":"Napier S","last_name":null,"full_name":null},{"first_name":"Olague A","last_name":null,"full_name":null},{"first_name":"Pack E","last_name":null,"full_name":null},{"first_name":"Padyana AK","last_name":null,"full_name":null},{"first_name":"Riether D","last_name":null,"full_name":null},{"first_name":"Simpson T.","last_name":null,"full_name":null},{"first_name":"Takahashi H","last_name":null,"full_name":null},{"first_name":"Thomson DS","last_name":null,"full_name":null},{"first_name":"Tye H","last_name":null,"full_name":null},{"first_name":"Wu L","last_name":null,"full_name":null},{"first_name":"Zindell RM","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/4032","landing_page":"https:\/\/molmedb.upol.cz\/publication\/4032","created_at":"2024-05-21T20:14:43.000000Z","updated_at":null}}