{"data":{"id":3826,"citation":"Cid JM, Tresadern G, Vega JA, de Lucas AI, Del Cerro A, Matesanz E, Linares ML, Garc\u00eda A, Iturrino L, P\u00e9rez-Benito L, Macdonald GJ, Oehlrich D, Lavreysen H, Peeters L, Ceusters M, Ahnaou A, Drinkenburg W, Mackie C, Somers M, Trabanco AA.: Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM). J Med Chem, Volume 59 (18), 2016","title":"Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)methyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).","doi":"10.1021\/acs.jmedchem.6b00913","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.6b00913","pmid":"27579727","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/27579727\/","year":2016,"journal":"J Med Chem","volume":"59","issue":"18","page":"8495-8507","authors":[{"first_name":"Ahnaou A","last_name":null,"full_name":null},{"first_name":"Ceusters M","last_name":null,"full_name":null},{"first_name":"Cid JM","last_name":null,"full_name":null},{"first_name":"de Lucas AI","last_name":null,"full_name":null},{"first_name":"Del Cerro A","last_name":null,"full_name":null},{"first_name":"Drinkenburg W","last_name":null,"full_name":null},{"first_name":"Garc\u00eda A","last_name":null,"full_name":null},{"first_name":"Iturrino L","last_name":null,"full_name":null},{"first_name":"Lavreysen H","last_name":null,"full_name":null},{"first_name":"Linares ML","last_name":null,"full_name":null},{"first_name":"Macdonald GJ","last_name":null,"full_name":null},{"first_name":"Mackie C","last_name":null,"full_name":null},{"first_name":"Matesanz E","last_name":null,"full_name":null},{"first_name":"Oehlrich D","last_name":null,"full_name":null},{"first_name":"Peeters L","last_name":null,"full_name":null},{"first_name":"P\u00e9rez-Benito L","last_name":null,"full_name":null},{"first_name":"Somers M","last_name":null,"full_name":null},{"first_name":"Trabanco AA.","last_name":null,"full_name":null},{"first_name":"Tresadern G","last_name":null,"full_name":null},{"first_name":"Vega JA","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3826","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3826","created_at":"2024-05-21T20:13:35.000000Z","updated_at":null}}