{"data":{"id":3763,"citation":"Lab\u00e9gu\u00e8re F, Dupont S, Alvey L, Soulas F, Newsome G, Tirera A, Quenehen V, Mai TTT, Deprez P, Blanqu\u00e9 R, Oste L, Le Tallec S, De Vos S, Hagers A, Vandevelde A, Nelles L, Vandervoort N, Conrath K, Christophe T, van der Aar E, Wakselman E, Merciris D, Cottereaux C, da Costa C, Saniere L, Clement-Lacroix P, Jenkins L, Milligan G, Fletcher S, Brys R, Gosmini R.: Discovery of 9-Cyclopropylethynyl-2-((<i>S<\/i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a<\/i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial. J Med Chem, Volume 63 (22), 2020","title":"Discovery of 9-Cyclopropylethynyl-2-((<i>S<\/i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a<\/i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.","doi":"10.1021\/acs.jmedchem.0c00272","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00272","pmid":"32902984","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32902984\/","year":2020,"journal":"J Med Chem","volume":"63","issue":"22","page":"13526-13545","authors":[{"first_name":"Alvey L","last_name":null,"full_name":null},{"first_name":"Blanque R","last_name":null,"full_name":null},{"first_name":"Brys R","last_name":null,"full_name":null},{"first_name":"Christophe T","last_name":null,"full_name":null},{"first_name":"Clement-Lacroix P","last_name":null,"full_name":null},{"first_name":"Conrath K","last_name":null,"full_name":null},{"first_name":"Cottereaux C","last_name":null,"full_name":null},{"first_name":"da Costa C","last_name":null,"full_name":null},{"first_name":"De Vos S","last_name":null,"full_name":null},{"first_name":"Deprez P","last_name":null,"full_name":null},{"first_name":"Dupont S","last_name":null,"full_name":null},{"first_name":"Fletcher S","last_name":null,"full_name":null},{"first_name":"Gosmini R.","last_name":null,"full_name":null},{"first_name":"Hagers A","last_name":null,"full_name":null},{"first_name":"Jenkins L","last_name":null,"full_name":null},{"first_name":"Lab\u00e9gu\u00e8re F","last_name":null,"full_name":null},{"first_name":"Le Tallec S","last_name":null,"full_name":null},{"first_name":"Mai TTT","last_name":null,"full_name":null},{"first_name":"Merciris D","last_name":null,"full_name":null},{"first_name":"Milligan G","last_name":null,"full_name":null},{"first_name":"Nelles L","last_name":null,"full_name":null},{"first_name":"Newsome G","last_name":null,"full_name":null},{"first_name":"Oste L","last_name":null,"full_name":null},{"first_name":"Quenehen V","last_name":null,"full_name":null},{"first_name":"Saniere L","last_name":null,"full_name":null},{"first_name":"Soulas F","last_name":null,"full_name":null},{"first_name":"Tirera A","last_name":null,"full_name":null},{"first_name":"van der Aar E","last_name":null,"full_name":null},{"first_name":"Vandervoort N","last_name":null,"full_name":null},{"first_name":"Vandevelde A","last_name":null,"full_name":null},{"first_name":"Wakselman E","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3763","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3763","created_at":"2024-05-21T20:13:17.000000Z","updated_at":null}}