{"data":{"id":3761,"citation":"William AD, Lee AC, Poulsen A, Goh KC, Madan B, Hart S, Tan E, Wang H, Nagaraj H, Chen D, Lee CP, Sun ET, Jayaraman R, Pasha MK, Ethirajulu K, Wood JM, Dymock BW.: Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2\/fms-like tyrosine kinase-3 (JAK2\/FLT3) for the treatment of rheumatoid arthritis. J Med Chem, Volume 55 (6), 2012","title":"Discovery of the macrocycle (9E)-15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a potent inhibitor of janus kinase 2\/fms-like tyrosine kinase-3 (JAK2\/FLT3) for the treatment of rheumatoid arthritis.","doi":"10.1021\/jm201454n","doi_url":"https:\/\/doi.org\/10.1021\/jm201454n","pmid":"22339472","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/22339472\/","year":2012,"journal":"J Med Chem","volume":"55","issue":"6","page":"2623-2640","authors":[{"first_name":"Chen D","last_name":null,"full_name":null},{"first_name":"Dymock BW.","last_name":null,"full_name":null},{"first_name":"Ethirajulu K","last_name":null,"full_name":null},{"first_name":"Goh KC","last_name":null,"full_name":null},{"first_name":"Hart S","last_name":null,"full_name":null},{"first_name":"Jayaraman R","last_name":null,"full_name":null},{"first_name":"Lee AC","last_name":null,"full_name":null},{"first_name":"Lee CP","last_name":null,"full_name":null},{"first_name":"Madan B","last_name":null,"full_name":null},{"first_name":"Nagaraj H","last_name":null,"full_name":null},{"first_name":"Pasha MK","last_name":null,"full_name":null},{"first_name":"Poulsen A","last_name":null,"full_name":null},{"first_name":"Sun ET","last_name":null,"full_name":null},{"first_name":"Tan E","last_name":null,"full_name":null},{"first_name":"Wang H","last_name":null,"full_name":null},{"first_name":"William AD","last_name":null,"full_name":null},{"first_name":"Wood JM","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3761","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3761","created_at":"2024-05-21T20:13:16.000000Z","updated_at":null}}