{"data":{"id":3716,"citation":"Kelly MJ, Pietranico-Cole S, Larigan JD, Haynes NE, Reynolds CH, Scott N, Vermeulen J, Dvorozniak M, Conde-Knape K, Huang KS, So SS, Thakkar K, Qian Y, Banner B, Mennona F, Danzi S, Klein I, Taub R, Tilley J.: Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor \u03b2 agonist in clinical trials for the treatment of dyslipidemia. J Med Chem, Volume 57 (10), 2014","title":"Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor \u03b2 agonist in clinical trials for the treatment of dyslipidemia.","doi":"10.1021\/jm4019299","doi_url":"https:\/\/doi.org\/10.1021\/jm4019299","pmid":"24712661","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/24712661\/","year":2014,"journal":"J Med Chem","volume":"57","issue":"10","page":"3912-3923","authors":[{"first_name":"Banner B","last_name":null,"full_name":null},{"first_name":"Conde-Knape K","last_name":null,"full_name":null},{"first_name":"Danzi S","last_name":null,"full_name":null},{"first_name":"Dvorozniak M","last_name":null,"full_name":null},{"first_name":"Haynes NE","last_name":null,"full_name":null},{"first_name":"Huang KS","last_name":null,"full_name":null},{"first_name":"Kelly MJ","last_name":null,"full_name":null},{"first_name":"Klein I","last_name":null,"full_name":null},{"first_name":"Larigan JD","last_name":null,"full_name":null},{"first_name":"Mennona F","last_name":null,"full_name":null},{"first_name":"Pietranico-Cole S","last_name":null,"full_name":null},{"first_name":"Qian Y","last_name":null,"full_name":null},{"first_name":"Reynolds CH","last_name":null,"full_name":null},{"first_name":"Scott N","last_name":null,"full_name":null},{"first_name":"So SS","last_name":null,"full_name":null},{"first_name":"Taub R","last_name":null,"full_name":null},{"first_name":"Thakkar K","last_name":null,"full_name":null},{"first_name":"Tilley J.","last_name":null,"full_name":null},{"first_name":"Vermeulen J","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3716","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3716","created_at":"2024-05-21T20:13:05.000000Z","updated_at":null}}