{"data":{"id":3654,"citation":"Lorthiois E, Roache J, Barnes-Seeman D, Altmann E, Hassiepen U, Turner G, Duvadie R, Hornak V, Karki RG, Schiering N, Weihofen WA, Perruccio F, Calhoun A, Fazal T, Dedic D, Durand C, Dussauge S, Fettis K, Tritsch F, Dentel C, Druet A, Liu D, Kirman L, Lachal J, Namoto K, Bevan D, Mo R, Monnet G, Muller L, Zessis R, Huang X, Lindsley L, Currie T, Chiu YH, Fridrich C, Delgado P, Wang S, Hollis-Symynkywicz M, Berghausen J, Williams E, Liu H, Liang G, Kim H, Hoffmann P, Hein A, Ramage P, D'Arcy A, Harlfinger S, Renatus M, Ruedisser S, Feldman D, Elliott J, Sedrani R, Maibaum J, Adams CM.: Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem, Volume 63 (15), 2020","title":"Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.","doi":"10.1021\/acs.jmedchem.0c00279","doi_url":"https:\/\/doi.org\/10.1021\/acs.jmedchem.0c00279","pmid":"32551603","pmid_url":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32551603\/","year":2020,"journal":"J Med Chem","volume":"63","issue":"15","page":"8088-8113","authors":[{"first_name":"Altmann E","last_name":null,"full_name":null},{"first_name":"Barnes-Seeman D","last_name":null,"full_name":null},{"first_name":"Bevan D","last_name":null,"full_name":null},{"first_name":"Calhoun A","last_name":null,"full_name":null},{"first_name":"Dedic D","last_name":null,"full_name":null},{"first_name":"Dentel C","last_name":null,"full_name":null},{"first_name":"Druet A","last_name":null,"full_name":null},{"first_name":"Durand C","last_name":null,"full_name":null},{"first_name":"Dussauge S","last_name":null,"full_name":null},{"first_name":"Duvadie R","last_name":null,"full_name":null},{"first_name":"Fazal T","last_name":null,"full_name":null},{"first_name":"Fettis K","last_name":null,"full_name":null},{"first_name":"Hassiepen U","last_name":null,"full_name":null},{"first_name":"Hornak V","last_name":null,"full_name":null},{"first_name":"Karki RG","last_name":null,"full_name":null},{"first_name":"Kirman L","last_name":null,"full_name":null},{"first_name":"Lachal J","last_name":null,"full_name":null},{"first_name":"Liu D","last_name":null,"full_name":null},{"first_name":"Lorthiois E","last_name":null,"full_name":null},{"first_name":"Namoto K","last_name":null,"full_name":null},{"first_name":"Perruccio F","last_name":null,"full_name":null},{"first_name":"Roache J","last_name":null,"full_name":null},{"first_name":"Schiering N","last_name":null,"full_name":null},{"first_name":"Tritsch F","last_name":null,"full_name":null},{"first_name":"Turner G","last_name":null,"full_name":null},{"first_name":"Weihofen WA","last_name":null,"full_name":null},{"first_name":"Adams CM.","last_name":null,"full_name":null},{"first_name":"Berghausen J","last_name":null,"full_name":null},{"first_name":"Chiu YH","last_name":null,"full_name":null},{"first_name":"Currie T","last_name":null,"full_name":null},{"first_name":"D'Arcy A","last_name":null,"full_name":null},{"first_name":"Delgado P","last_name":null,"full_name":null},{"first_name":"Elliott J","last_name":null,"full_name":null},{"first_name":"Feldman D","last_name":null,"full_name":null},{"first_name":"Fridrich C","last_name":null,"full_name":null},{"first_name":"Harlfinger S","last_name":null,"full_name":null},{"first_name":"Hein A","last_name":null,"full_name":null},{"first_name":"Hoffmann P","last_name":null,"full_name":null},{"first_name":"Hollis-Symynkywicz M","last_name":null,"full_name":null},{"first_name":"Huang X","last_name":null,"full_name":null},{"first_name":"Kim H","last_name":null,"full_name":null},{"first_name":"Liang G","last_name":null,"full_name":null},{"first_name":"Lindsley L","last_name":null,"full_name":null},{"first_name":"Liu H","last_name":null,"full_name":null},{"first_name":"Maibaum J","last_name":null,"full_name":null},{"first_name":"Mo R","last_name":null,"full_name":null},{"first_name":"Monnet G","last_name":null,"full_name":null},{"first_name":"Muller L","last_name":null,"full_name":null},{"first_name":"Ramage P","last_name":null,"full_name":null},{"first_name":"Renatus M","last_name":null,"full_name":null},{"first_name":"Ruedisser S","last_name":null,"full_name":null},{"first_name":"Sedrani R","last_name":null,"full_name":null},{"first_name":"Wang S","last_name":null,"full_name":null},{"first_name":"Williams E","last_name":null,"full_name":null},{"first_name":"Zessis R","last_name":null,"full_name":null}],"url":"https:\/\/molmedb.upol.cz\/api\/v1\/publications\/3654","landing_page":"https:\/\/molmedb.upol.cz\/publication\/3654","created_at":"2024-05-21T20:12:50.000000Z","updated_at":null}}